Self-Assembly Protein Nanogels for Safer Cancer Immunotherapy.
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ABSTRACT:
SUBMITTER: Purwada A
PROVIDER: S-EPMC5532174 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Publications
Self-Assembly Protein Nanogels for Safer Cancer Immunotherapy.
Purwada Alberto A Tian Ye F YF Huang Weishan W Rohrbach Kathleen M KM Deol Simrita S August Avery A Singh Ankur A
Advanced healthcare materials 20160421 12
Soluble antigen-based cancer vaccines have poor retention in tissues along with suboptimal antigen processing by dendritic cells. Multiple booster doses are often needed, leading to dose-limiting systemic toxicity. A versatile, immunomodulatory, self-assembly protein nanogel vaccine is reported that induces robust immune cell response at lower antigen doses than soluble antigens, an important step towards biomaterials-based safer immunotherapy approaches. ...[more]
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