Dataset Information

NF-kappa B activation correlates with disease phenotype in Crohn's disease.

ABSTRACT:

Background/aims

Unregulated activation of nuclear factor-?B (NF-?B) plays a critical role in the pathogenesis of Crohn's disease. In this study, we investigated the clinical characteristics and disease outcome of Crohn's disease patients with varying levels of the NF-?B activation.

Methods

Crohn's disease patients who underwent surgical bowel resection were divided into two groups, based on the activation status of NF-?B. NF-?B activation was assessed by the immunoreactivity of nuclear NF-?B during immunohistochemical staining of bowel resection specimens. We compared the demographic, clinical and histologic characteristics between groups. Furthermore, the occurrence of reoperation, readmission, and medication change due to disease flare-up were investigated according to NF-?B activation status.

Results

Among 83 Crohn's disease patients, 47 (56%) showed high NF-?B activity and 36 (44%) showed low NF-?B activity. Patients with high NF-?B activity had higher frequency of ileocolonic involvement (P = 0.028) and lower frequency of perianal involvement (P = 0.042) relative to those with low NF-?B activity. Total histologic scores were significantly higher in patients with high NF-?B activity than those with low NF-?B activity (P = 0.044). There was no significant difference in the frequency of reoperation, readmission, and medication change in relation to NF-?B activation status.

Conclusions

Crohn's disease patients with high NF-?B activation showed specific clinical manifestations of higher frequency of ileocolonic involvement and lower frequency of perianal involvement relative to those with low NF-?B activation. High NF-?B activity was associated with higher histologic scores. However, the NF-?B activity did not affect the outcome and disease course after surgery.

SUBMITTER: Han YM

PROVIDER: S-EPMC5533307 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Publications

NF-kappa B activation correlates with disease phenotype in Crohn's disease.

Han Yoo Min YM Koh Jaemoon J Kim Ji Won JW Lee Changhyun C Koh Seong-Joon SJ Kim ByeongGwan B Lee Kook Lae KL Im Jong Pil JP Kim Joo Sung JS

PloS one 20170728 7

<h4>Background/aims</h4>Unregulated activation of nuclear factor-κB (NF-κB) plays a critical role in the pathogenesis of Crohn's disease. In this study, we investigated the clinical characteristics and disease outcome of Crohn's disease patients with varying levels of the NF-κB activation.<h4>Methods</h4>Crohn's disease patients who underwent surgical bowel resection were divided into two groups, based on the activation status of NF-κB. NF-κB activation was assessed by the immunoreactivity of nu ...[more]

PMID: 28753650

Similar Datasets

Project description:AimTo investigate genotype-phenotype correlations in patients with perianal Crohn's disease (PCD) in order to determine which factors predispose to development of perianal disease in Crohn's patients.MethodsSeven-hundred and ninety-five Caucasian individuals (317 CD patients and 478 controls without inflammatory bowel disease, IBD) were prospectively enrolled into a clinical/genetic database. Demographic and clinical data, as well as peripheral blood leukocyte DNA were obtained from all patients. The following were evaluated: three NOD2/CARD15 polymorphisms: R702W, G908R, and 1007insC; five IL-23r risk alleles: rs1004819, rs10489629, rs2201841, rs11465804, and rs11209026; a well-characterized single-nucleotide polymorphism (SNP) on the IBD5 risk haplotype (OCTN1) and two peripheral tag SNPs (IGR2060 and IGR3096).ResultsPCD occurred in 147 (46%) of CD patients. There was no significant difference in the age at disease diagnosis between non-PCD and PCD patients (33 vs. 29 years, respectively). PCD patients were more likely to have disease located in the colon and ileocolic regions (79 PCD vs. 57% non-PCD; n = 116 vs. n = 96; p < 0.001), whereas patients with non-PCD were more likely to have Crohn's within the terminal ileum and upper gastrointestinal tract (43% non-PCD vs. 21% PCD; n = 73 vs. n = 31; p < 0.05). Thirty-four percent of patients with PCD required a permanent ileostomy (n = 50) compared to only 4% of non-PCD patients (n = 6; p < 0.05). Mutations in CARD15/NOD2 and IL-23r were risk factors for CD overall; however, in contrast to prior reports, in this patient population, OCTN1 and IGR variations within the IBD5 haplotype were not significant predictors of PCD.ConclusionColon/ileocolic CD location appears to be a significant predictor of perianal manifestations of CD. Patients with PCD are more likely to require permanent fecal diversion. We did not identify any genetic variations or combination of clinical findings and genetic variations within the CARD15/NOD2, IL-23r, and OCTN1 genes or IGR that were predictive of PCD.

Dataset Information

NF-kappa B activation correlates with disease phenotype in Crohn's disease.

Background/aims

Methods

Results

Conclusions

Publications

NF-kappa B activation correlates with disease phenotype in Crohn's disease.

Similar Datasets

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