Ontology highlight
ABSTRACT:
SUBMITTER: Wallenhammar A
PROVIDER: S-EPMC5533445 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Wallenhammar Amélie A Anandapadamanaban Madhanagopal M Lemak Alexander A Mirabello Claudio C Lundström Patrik P Wallner Björn B Sunnerhagen Maria M
PloS one 20170728 7
Tripartite motif-containing (TRIM) proteins are defined by the sequential arrangement of RING, B-box and coiled-coil domains (RBCC), where the B-box domain is a unique feature of the TRIM protein family. TRIM21 is an E3 ubiquitin-protein ligase implicated in innate immune signaling by acting as an autoantigen and by modifying interferon regulatory factors. Here we report the three-dimensional solution structure of the TRIM21 B-box2 domain by nuclear magnetic resonance (NMR) spectroscopy. The str ...[more]