Ontology highlight
ABSTRACT:
SUBMITTER: Gabriel TL
PROVIDER: S-EPMC5533446 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Gabriel Tanit L TL Mirzaian Mina M Hooibrink Berend B Ottenhoff Roelof R van Roomen Cindy C Aerts Johannes M F G JMFG van Eijk Marco M
PloS one 20170728 7
During obesity, adipose tissue macrophages (ATM) are increased in concert with local inflammation and insulin resistance. Since the levels of sphingolipid (SLs) in adipose tissue (AT) are altered during obesity we investigated the potential impact of SLs on ATMs. For this, we first analyzed expression of SL metabolizing genes in ATMs isolated from obese mice. A marked induction of sphingosine kinase 1 (Sphk1) expression was observed in obese ATM when compared to lean ATM. This induction was obse ...[more]