Ontology highlight
ABSTRACT:
SUBMITTER: Crichton JH
PROVIDER: S-EPMC5533463 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Crichton James H JH Playfoot Christopher J CJ MacLennan Marie M Read David D Cooke Howard J HJ Adams Ian R IR
PLoS genetics 20170714 7
Meiosis relies on the SPO11 endonuclease to generate the recombinogenic DNA double strand breaks (DSBs) required for homologous chromosome synapsis and segregation. The number of meiotic DSBs needs to be sufficient to allow chromosomes to search for and find their homologs, but not excessive to the point of causing genome instability. Here we report that the mammal-specific gene Tex19.1 promotes Spo11-dependent recombination in mouse spermatocytes. We show that the chromosome asynapsis previousl ...[more]