Ontology highlight
ABSTRACT:
SUBMITTER: Zelazowski MJ
PROVIDER: S-EPMC5679441 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Zelazowski Maciej J MJ Sandoval Maria M Paniker Lakshmi L Hamilton Holly M HM Han Jiaying J Gribbell Mikalah A MA Kang Rhea R Cole Francesca F
Cell 20170921 3
Faithful chromosome segregation in meiosis requires crossover (CO) recombination, which is regulated to ensure at least one CO per homolog pair. We investigate the failure to ensure COs in juvenile male mice. By monitoring recombination genome-wide using cytological assays and at hotspots using molecular assays, we show that juvenile mouse spermatocytes have fewer COs relative to adults. Analysis of recombination in the absence of MLH3 provides evidence for greater utilization in juveniles of pa ...[more]