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Structure and function of HWE/HisKA2-family sensor histidine kinases.

ABSTRACT: Sensor histidine kinases regulate adaptive cellular responses to changes in the chemical or physical state of the environment. HWE/HisKA2-family kinases comprise a subset of histidine kinases that is defined by unique sequence motifs in both the catalytic and non-catalytic regions. Recent crystal structures have defined conserved intramolecular interactions that inform models of kinase regulation that are unique to the HWE/HisKA2 superfamily. Emerging genetic, biochemical and genomic data indicate that, unlike typical histidine kinases, HWE/HisKA2 kinases do not generally signal via classical DNA-binding response regulators. Rather, these unusual kinases are often part of atypical regulatory pathways that control changes in gene expression via modulation of protein-protein interactions or transcription anti-termination.

SUBMITTER: Herrou J

PROVIDER: S-EPMC5534388 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature

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Structure and function of HWE/HisKA2-family sensor histidine kinases.

Herrou Julien J Crosson Sean S Fiebig Aretha A

Current opinion in microbiology 20170211

Sensor histidine kinases regulate adaptive cellular responses to changes in the chemical or physical state of the environment. HWE/HisKA2-family kinases comprise a subset of histidine kinases that is defined by unique sequence motifs in both the catalytic and non-catalytic regions. Recent crystal structures have defined conserved intramolecular interactions that inform models of kinase regulation that are unique to the HWE/HisKA2 superfamily. Emerging genetic, biochemical and genomic data indica ...[more]

PMID: 28193573

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