Emerging molecular targets and therapy for cholangiocarcinoma.
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ABSTRACT:
SUBMITTER: Kayhanian H
PROVIDER: S-EPMC5534395 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Publications
Emerging molecular targets and therapy for cholangiocarcinoma.
Kayhanian Hamzeh H Smyth Elizabeth C EC Braconi Chiara C
World journal of gastrointestinal oncology 20170701 7
Cholangiocarcinoma (CCA) is a rare cancer arising from the biliary tree with a poor prognosis and limited therapeutic options. Recent large scale molecular characterisation studies have identified recurrent genetic alterations in CCA which may be amenable to therapeutic targeting. In this review we explore the genomic landscape of CCA and examine results from trials of molecularly targeted agents and immunotherapy in this disease. Challenges in CCA diagnosis, treatment and trial design are discu ...[more]
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