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Clinical significance of autoantibodies in a large cohort of patients with chronic graft-versus-host disease defined by NIH criteria.

ABSTRACT: There is an unmet need for identifying new clinical biomarkers in chronic Graft-versus-Host-disease (cGVHD) suitable for diagnosis and disease monitoring. Circulating autoantibodies represent an ongoing immune response and suggest a pathogenic role for B cells in cGVHD. Autoantibodies could be useful markers of cGVHD disease activity, severity, or organ specificity; however, their clinical utility is not established. The focus of this study was to determine the incidence and associations of a broad array of clinical autoantibodies with cGVHD manifestations in a large patient cohort characterized by NIH criteria. A panel of 21 circulating antibodies commonly used in clinical medicine was tested in 280 cGVHD patients (70% severe) enrolled in a cross-sectional prospective natural history study. Median cGVHD duration was two years. Patients with circulating autoantibodies (62%) had significantly higher levels of IgM (P?

SUBMITTER: Kuzmina Z 

PROVIDER: S-EPMC5535796 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature

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Clinical significance of autoantibodies in a large cohort of patients with chronic graft-versus-host disease defined by NIH criteria.

Kuzmina Zoya Z   Gounden Verena V   Curtis Lauren L   Avila Daniele D   Rnp Tiffani Taylor TT   Baruffaldi Judy J   Cowen Edward W EW   Naik Haley B HB   Hasni Sarfaraz A SA   Mays Jacqueline W JW   Mitchell Sandra S   Baird Kristin K   Steinberg Seth M SM   Pavletic Steven Z SZ  

American journal of hematology 20141124 2

There is an unmet need for identifying new clinical biomarkers in chronic Graft-versus-Host-disease (cGVHD) suitable for diagnosis and disease monitoring. Circulating autoantibodies represent an ongoing immune response and suggest a pathogenic role for B cells in cGVHD. Autoantibodies could be useful markers of cGVHD disease activity, severity, or organ specificity; however, their clinical utility is not established. The focus of this study was to determine the incidence and associations of a br  ...[more]

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