Ontology highlight
ABSTRACT:
SUBMITTER: Sohn BH
PROVIDER: S-EPMC5536176 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Sohn Bo Hwa BH Shim Jae-Jun JJ Kim Sang-Bae SB Jang Kyu Yun KY Kim Soo Mi SM Kim Ji Hoon JH Hwang Jun Eul JE Jang Hee-Jin HJ Lee Hyun-Sung HS Kim Sang-Cheol SC Jeong Woojin W Kim Sung Soo SS Park Eun Sung ES Heo Jeonghoon J Kim Yoon Jun YJ Kim Dae-Ghon DG Leem Sun-Hee SH Kaseb Ahmed A Hassan Manal M MM Cha Minse M Chu In-Sun IS Johnson Randy L RL Park Yun-Yong YY Lee Ju-Seog JS
Clinical cancer research : an official journal of the American Association for Cancer Research 20151012 5
<h4>Purpose</h4>The Hippo pathway is a tumor suppressor in the liver. However, the clinical significance of Hippo pathway inactivation in HCC is not clearly defined. We analyzed genomic data from human and mouse tissues to determine clinical relevance of Hippo pathway inactivation in HCC.<h4>Experimental design</h4>We analyzed gene expression data from Mst1/2(-/-) and Sav1(-/-) mice and identified a 610-gene expression signature reflecting Hippo pathway inactivation in the liver [silence of Hipp ...[more]