Ontology highlight
ABSTRACT:
SUBMITTER: Mi L
PROVIDER: S-EPMC5537633 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Mi L L Zhu F F Yang X X Lu J J Zheng Y Y Zhao Q Q Wen X X Lu A A Wang M M Zheng M M Ji J J Sun J J
Oncogene 20170327 30
N-myc downstream-regulated gene 1 (NDRG1) has been reported to act as a key regulatory molecule in tumor progression-related signaling pathways, especially in tumor metastasis. However, the related mechanism has not been fully discovered yet. Herein we demonstrated that the novel molecule of cell migration and invasion, caveolin-1, has direct interaction with NDRG1 in human colorectal cancer (CRC) cells. Moreover, we discovered that NDRG1 reduces caveolin-1 protein expression through promoting i ...[more]