Ontology highlight
ABSTRACT:
SUBMITTER: Satapati S
PROVIDER: S-EPMC5538279 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Satapati Santhosh S Qian Ying Y Wu Margaret S MS Petrov Aleksandr A Dai Ge G Wang Sheng-Ping SP Zhu Yonghua Y Shen Xiaolan X Muise Eric S ES Chen Ying Y Zycband Emanuel E Weinglass Adam A Di Salvo Jerry J Debenham John S JS Cox Jason M JM Lan Ping P Shah Vinit V Previs Stephen F SF Erion Mark M Kelley David E DE Wang Liangsu L Howard Andrew D AD Shang Jin J
Journal of lipid research 20170605 8
GPR40 and GPR120 are fatty acid sensors that play important roles in glucose and energy homeostasis. GPR40 potentiates glucose-dependent insulin secretion and demonstrated in clinical studies robust glucose lowering in type 2 diabetes. GPR120 improves insulin sensitivity in rodents, albeit its mechanism of action is not fully understood. Here, we postulated that the antidiabetic efficacy of GPR40 could be enhanced by coactivating GPR120. A combination of GPR40 and GPR120 agonists in <i>db</i>/<i ...[more]