Ontology highlight
ABSTRACT:
SUBMITTER: Smith MP
PROVIDER: S-EPMC5538298 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Smith Michael P MP Rowling Emily J EJ Miskolczi Zsofia Z Ferguson Jennifer J Spoerri Loredana L Haass Nikolas K NK Sloss Olivia O McEntegart Sophie S Arozarena Imanol I von Kriegsheim Alex A Rodriguez Javier J Brunton Holly H Kmarashev Jivko J Levesque Mitchell P MP Dummer Reinhard R Frederick Dennie T DT Andrews Miles C MC Cooper Zachary A ZA Flaherty Keith T KT Wargo Jennifer A JA Wellbrock Claudia C
EMBO molecular medicine 20170801 8
Approaches to prolong responses to BRAF targeting drugs in melanoma patients are challenged by phenotype heterogeneity. Melanomas of a "MITF-high" phenotype usually respond well to BRAF inhibitor therapy, but these melanomas also contain subpopulations of the <i>de novo</i> resistance "AXL-high" phenotype. > 50% of melanomas progress with enriched "AXL-high" populations, and because AXL is linked to de-differentiation and invasiveness avoiding an "AXL-high relapse" is desirable. We discovered th ...[more]