Ontology highlight
ABSTRACT:
SUBMITTER: Hua W
PROVIDER: S-EPMC5538693 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Hua Wenfeng W Zhang Anqi A Duan Ping P Zhu Jinhong J Zhao Yuan Y He Jing J Zhang Zhi Z
OncoTargets and therapy 20170727
Studies have shown that single-nucleotide polymorphisms in <i>MDM2</i> gene may play important roles in the development of malignant tumor. The association of del1518 polymorphism (rs3730485) in the <i>MDM2</i> promoter with cancer susceptibility has been extensively studied; however, the results are contradictory. To quantify the association between this polymorphism and overall cancer risk, we conducted a meta-analysis with 12,905 cases and 10,026 controls from 16 eligible studies retrieved fr ...[more]