Hypomethylation of CNTFR? is associated with proliferation and poor prognosis in lower grade gliomas.
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ABSTRACT:
SUBMITTER: Fan K
PROVIDER: S-EPMC5539284 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
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Hypomethylation of CNTFRα is associated with proliferation and poor prognosis in lower grade gliomas.
Fan Kun K Wang Xiaowen X Zhang Jingwen J Ramos Romela Irene RI Zhang Haibo H Li Chunjie C Ye Dan D Kang Jiansheng J Marzese Diego M DM Hoon Dave S B DSB Hua Wei W
Scientific reports 20170801 1
Ciliary neurotrophic factor receptor α subunit (CNTFRα) and CNTF play important roles in neuron survival, glial differentiation and brain tumor growth. However, the molecular mechanisms of CNTFRα regulation and its clinical significance in glioma remain largely unknown. Here, we found CNTFRα was overexpressed in lower grade gliomas (LGG) compared with glioblastoma (GBM) and normal brain specimens in TCGA datasets and in an independent cohort. Bioinformatics analysis revealed a CpG shore of the C ...[more]
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