Ontology highlight
ABSTRACT:
SUBMITTER: Wong CO
PROVIDER: S-EPMC5540652 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Wong Ching-On CO Gregory Steven S Hu Hongxiang H Chao Yufang Y Sepúlveda Victoria E VE He Yuchun Y Li-Kroeger David D Goldman William E WE Bellen Hugo J HJ Venkatachalam Kartik K
Cell host & microbe 20170601 6
Clearance of bacteria by macrophages involves internalization of the microorganisms into phagosomes, which are then delivered to endolysosomes for enzymatic degradation. These spatiotemporally segregated processes are not known to be functionally coupled. Here, we show that lysosomal degradation of bacteria sustains phagocytic uptake. In Drosophila and mammalian macrophages, lysosomal dysfunction due to loss of the endolysosomal Cl<sup>-</sup> transporter ClC-b/CLCN7 delayed degradation of inter ...[more]