Ontology highlight
ABSTRACT:
SUBMITTER: Muhlrad D
PROVIDER: S-EPMC554118 | biostudies-literature | 2005 Mar
REPOSITORIES: biostudies-literature
The EMBO journal 20050210 5
A major mechanism of eukaryotic mRNA degradation initiates with deadenylation followed by decapping and 5' to 3' degradation. We demonstrate that the yeast EDC1 mRNA, which encodes a protein that enhances decapping, has unique properties and is both protected from deadenylation and undergoes deadenylation-independent decapping. The 3' UTR of the EDC1 mRNA is sufficient for both protection from deadenylation and deadenylation-independent decapping and an extended poly(U) tract within the 3' UTR i ...[more]