Direct C-H Cyanation of Arenes via Organic Photoredox Catalysis.

ABSTRACT: Methods for the direct C-H functionalization of aromatic compounds are in demand for a variety of applications, including the synthesis of agrochemicals, pharmaceuticals, and materials. Herein, we disclose the construction of aromatic nitriles via direct C-H functionalization using an acridinium photoredox catalyst and trimethylsilyl cyanide under an aerobic atmosphere. The reaction proceeds at room temperature under mild conditions and has proven to be compatible with a variety of electron-donating and -withdrawing groups, halogens, and nitrogen- and oxygen-containing heterocycles, as well as aromatic-containing pharmaceutical agents.

SUBMITTER: McManus JB 

PROVIDER: S-EPMC5541851 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature