Ontology highlight
ABSTRACT:
SUBMITTER: Chen W
PROVIDER: S-EPMC6680023 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Chen Wei W Huang Zeng Z Tay Nicholas E S NES Giglio Benjamin B Wang Mengzhe M Wang Hui H Wu Zhanhong Z Nicewicz David A DA Li Zibo Z
Science (New York, N.Y.) 20190601 6446
Positron emission tomography (PET) plays key roles in drug discovery and development, as well as medical imaging. However, there is a dearth of efficient and simple radiolabeling methods for aromatic C-H bonds, which limits advancements in PET radiotracer development. Here, we disclose a mild method for the fluorine-18 (<sup>18</sup>F)-fluorination of aromatic C-H bonds by an [<sup>18</sup>F]F<sup>-</sup> salt via organic photoredox catalysis under blue light illumination. This strategy was appl ...[more]