Ontology highlight
ABSTRACT:
SUBMITTER: Hong S
PROVIDER: S-EPMC5542066 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Hong Samuel S Cheng Xiaodong X
Advances in experimental medicine and biology 20160101
The modification of DNA bases is a classic hallmark of epigenetics. Four forms of modified cytosine-5-methylcytosine, 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine-have been discovered in eukaryotic DNA. In addition to cytosine carbon-5 modifications, cytosine and adenine methylated in the exocyclic amine-N4-methylcytosine and N6-methyladenine-are other modified DNA bases discovered even earlier. Each modified base can be considered a distinct epigenetic signal with broader b ...[more]