Ontology highlight
ABSTRACT:
SUBMITTER: Michalik M
PROVIDER: S-EPMC5542473 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Michalik Marcin M Orwick-Rydmark Marcella M Habeck Michael M Alva Vikram V Arnold Thomas T Linke Dirk D
PloS one 20170803 8
An intimate interaction between a pair of amino acids, a tyrosine and glycine on neighboring β-strands, has been previously reported to be important for the structural stability of autotransporters. Here, we show that the conservation of this interacting pair extends to nearly all major families of outer membrane β-barrel proteins, which are thought to have originated through duplication events involving an ancestral ββ hairpin. We analyzed the function of this motif using the prototypical outer ...[more]