Optimal diagnostic thresholds for diagnosis of orthostatic hypotension with a 'sit-to-stand test'.

ABSTRACT: OBJECTIVE:This study aimed to identify optimal blood pressure cut-offs to diagnose orthostatic hypotension during a sit-to-stand manoeuvre. METHODS:This was a cross-sectional study of patients and healthy controls from the Vanderbilt Autonomic Dysfunction Center. Blood pressure was measured while supine, seated and standing. Blood pressure changes were calculated from supine-to-standing and seated-to-standing. Orthostatic hypotension was diagnosed on the basis of a supine-to-standing SBP drop at least 20?mmHg or a DBP drop at least 10?mmHg. Receiver operator characteristic (ROC) curves identified optimal sit-to-stand cut-offs. RESULTS:Amongst the 831 individuals, more had systolic orthostatic hypotension [n?=?354 (43%)] than diastolic orthostatic hypotension [n?=?305 (37%)] during lying-to-standing. The ROC curves had good characteristics [SBP area under curve?=?0.916 (95% confidence interval: 0.896-0.936), P?

SUBMITTER: Shaw BH 

PROVIDER: S-EPMC5542884 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature