Solution nuclear magnetic resonance spectroscopy on a nanostructured diamond chip.

ABSTRACT: Sensors using nitrogen-vacancy centers in diamond are a promising tool for small-volume nuclear magnetic resonance (NMR) spectroscopy, but the limited sensitivity remains a challenge. Here we show nearly two orders of magnitude improvement in concentration sensitivity over previous nitrogen-vacancy and picoliter NMR studies. We demonstrate NMR spectroscopy of picoliter-volume solutions using a nanostructured diamond chip with dense, high-aspect-ratio nanogratings, enhancing the surface area by 15 times. The nanograting sidewalls are doped with nitrogen-vacancies located a few nanometers from the diamond surface to detect the NMR spectrum of roughly 1 pl of fluid lying within adjacent nanograting grooves. We perform ¹H and ¹⁹F nuclear magnetic resonance spectroscopy at

SUBMITTER: Kehayias P 

PROVIDER: S-EPMC5543112 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature