Ontology highlight
ABSTRACT:
SUBMITTER: Sijbesma E
PROVIDER: S-EPMC5543393 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Sijbesma Eline E Skora Lukasz L Leysen Seppe S Brunsveld Luc L Koch Uwe U Nussbaumer Peter P Jahnke Wolfgang W Ottmann Christian C
Biochemistry 20170721 30
Proteins typically interact with multiple binding partners, and often different parts of their surfaces are employed to establish these protein-protein interactions (PPIs). Members of the class of 14-3-3 adapter proteins bind to several hundred other proteins in the cell. Multiple small molecules for the modulation of 14-3-3 PPIs have been disclosed; however, they all target the conserved phosphopeptide binding channel, so that selectivity is difficult to achieve. Here we report on the discovery ...[more]