Presence of bone marrow micrometastasis is associated with different recurrence risk within molecular subtypes of breast cancer.
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ABSTRACT:
SUBMITTER: Naume B
PROVIDER: S-EPMC5543886 | biostudies-literature | 2007 Sep
REPOSITORIES: biostudies-literature
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Presence of bone marrow micrometastasis is associated with different recurrence risk within molecular subtypes of breast cancer.
Naume Bjørn B Zhao Xi X Synnestvedt Marit M Borgen Elin E Russnes Hege Giercksky HG Lingjaerde Ole Christian OC Strømberg Maria M Wiedswang Gro G Kvalheim Gunnar G Kåresen Rolf R Nesland Jahn M JM Børresen-Dale Anne-Lise AL Sørlie Therese T
Molecular oncology 20070404 2
Expression profiles of primary breast tumors were investigated in relation to disseminated tumor cells (DTCs) in bone marrow (BM) in order to increase our understanding of the dissemination process. Tumors were classified into five pre-defined molecular subtypes, and presence of DTC identified (at median 85 months follow-up) a subgroup of luminal A patients with particular poor outcome (p=0.008). This was not apparent for other tumor subtypes. Gene expression profiles associated with DTC and wit ...[more]
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