Ontology highlight
ABSTRACT:
SUBMITTER: Pearce SF
PROVIDER: S-EPMC5544427 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Pearce Sarah F SF Rorbach Joanna J Van Haute Lindsey L D'Souza Aaron R AR Rebelo-Guiomar Pedro P Powell Christopher A CA Brierley Ian I Firth Andrew E AE Minczuk Michal M
eLife 20170726
Human mitochondria contain a genome (mtDNA) that encodes essential subunits of the oxidative phosphorylation system. Expression of mtDNA entails multi-step maturation of precursor RNA. In other systems, the RNA life cycle involves surveillance mechanisms, however, the details of RNA quality control have not been extensively characterised in human mitochondria. Using a mitochondrial ribosome profiling and mitochondrial poly(A)-tail RNA sequencing (MPAT-Seq) assay, we identify the poly(A)-specific ...[more]