Intraoperative Functional Ultrasound Imaging of Human Brain Activity.

ABSTRACT: The functional mapping of brain activity is essential to perform optimal glioma surgery and to minimize the risk of postoperative deficits. We introduce a new, portable neuroimaging modality of the human brain based on functional ultrasound (fUS) for deep functional cortical mapping. Using plane-wave transmissions at an ultrafast frame rate (1 kHz), fUS is performed during surgery to measure transient changes in cerebral blood volume with a high spatiotemporal resolution (250 µm, 1 ms). fUS identifies, maps and differentiates regions of brain activation during task-evoked cortical responses within the depth of a sulcus in both awake and anaesthetized patients.

SUBMITTER: Imbault M 

PROVIDER: S-EPMC5544759 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature