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4D functional ultrasound imaging of whole-brain activity in rodents.

ABSTRACT: We extended the capabilities of functional ultrasound to whole-brain four-dimensional (4D) neuroimaging. Our multiplane-wave transmission scheme on matrix arrays at thousands of frames per second provides volumetric recordings of cerebral blood volume changes at high spatiotemporal resolution. We illustrated the approach in rats while providing multiple sensory stimuli, for 4D functional connectivity and during instantaneous tracking of epileptiform events.

SUBMITTER: Rabut C

PROVIDER: S-EPMC6774790 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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4D functional ultrasound imaging of whole-brain activity in rodents.

Rabut Claire C Correia Mafalda M Finel Victor V Pezet Sophie S Pernot Mathieu M Deffieux Thomas T Tanter Mickael M

Nature methods 20190923 10

We extended the capabilities of functional ultrasound to whole-brain four-dimensional (4D) neuroimaging. Our multiplane-wave transmission scheme on matrix arrays at thousands of frames per second provides volumetric recordings of cerebral blood volume changes at high spatiotemporal resolution. We illustrated the approach in rats while providing multiple sensory stimuli, for 4D functional connectivity and during instantaneous tracking of epileptiform events. ...[more]

PMID: 31548704

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