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TGF-? in pancreatic cancer initiation and progression: two sides of the same coin.

ABSTRACT: Pancreatic cancer is highly lethal malignant tumor with characterised rapid progression, invasiveness and resistance to radiochemotherapy. Transforming growth factor-? (TGF-?) signaling plays a dual role in both pro-tumorigenic and tumor suppressive of pancreatic cancer, depending on tumor stage and microenvironment. TGF-? signaling components alteration are common in pancreatic cancer, and its leading role in tumor formation and metastases has received increased attention. Many therapies have investigated to target TGF-? signaling in the preclinical and clinical setting. In this review, we highlight the dual roles of TGF-? and touch upon the perspectives on therapeutic target of TGF-? signaling in pancreatic cancer.

SUBMITTER: Shen W

PROVIDER: S-EPMC5545849 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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TGF-β in pancreatic cancer initiation and progression: two sides of the same coin.

Shen Wei W Tao Guo-Qing GQ Zhang Yu Y Cai Bing B Sun Jian J Tian Zhi-Qiang ZQ

Cell & bioscience 20170807

Pancreatic cancer is highly lethal malignant tumor with characterised rapid progression, invasiveness and resistance to radiochemotherapy. Transforming growth factor-β (TGF-β) signaling plays a dual role in both pro-tumorigenic and tumor suppressive of pancreatic cancer, depending on tumor stage and microenvironment. TGF-β signaling components alteration are common in pancreatic cancer, and its leading role in tumor formation and metastases has received increased attention. Many therapies have i ...[more]

PMID: 28794854

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