Dataset Information

Cognitive Status, Gray Matter Atrophy, and Lower Orthostatic Blood Pressure in Older Adults.

ABSTRACT: BACKGROUND:Associations between orthostatic blood pressure and cognitive status (CS) have been described with conflicting results. OBJECTIVE:We hypothesize that long-term exposure to lower orthostatic blood pressure is related to having worse CS later in life and that atrophy of regions involved in central regulation of autonomic function mediate these associations. METHODS:Three-to-four measures of orthostatic blood pressure were obtained from 1997-2003 in a longitudinal cohort of aging, and average systolic orthostatic blood pressure response (ASOBPR) was computed as % change in systolic blood pressure from sit-to-stand measured at one minute post stand. CS was determined in 2010-2012 by clinician-adjudication (n?=?240; age?=?87.1±2.6; 59% women; 37% black) with a subsample also undergoing concurrent structural neuroimaging (n?=?129). Gray matter volume of regions related to autonomic function was measured. Multinomial regression was used to compare ASOBPR in those who were cognitively intact versus those with a diagnosis of mild cognitive impairment or dementia, controlling for demographics, trajectories of seated blood pressure, incident cardiovascular risk/events and medications measured from 1997 to 2012. Models were repeated in the subsample with neuroimaging, before and after adjustment for regional gray matter volume. RESULTS:There was an inverse association between ASOBPR and probability of dementia diagnosis (9% lower probability for each % point higher ASOBPR: OR 0.91, CI95% ?=?0.85-0.98; p?=?0.01). Associations were similar in the subgroup with neuroimaging before and after adjustment for regional gray matter volume. CONCLUSION:ASOBPR may be an early marker of risk of dementia in older adults living in the community.

SUBMITTER: O'Hare C

PROVIDER: S-EPMC5545885 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Cognitive Status, Gray Matter Atrophy, and Lower Orthostatic Blood Pressure in Older Adults.

O'Hare Celia C Kenny Rose-Anne RA Aizenstein Howard H Boudreau Robert R Newman Anne A Launer Lenore L Satterfield Suzanne S Yaffe Kristine K Rosano Caterina C

Journal of Alzheimer's disease : JAD 20170101 4

<h4>Background</h4>Associations between orthostatic blood pressure and cognitive status (CS) have been described with conflicting results.<h4>Objective</h4>We hypothesize that long-term exposure to lower orthostatic blood pressure is related to having worse CS later in life and that atrophy of regions involved in central regulation of autonomic function mediate these associations.<h4>Methods</h4>Three-to-four measures of orthostatic blood pressure were obtained from 1997-2003 in a longitudinal c ...[more]

PMID: 28339397

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Project description:Background: Voxel-based morphometry (VBM) has been widely used to investigate structural alterations in amnesia mild cognitive impairment (aMCI). However, inconsistent results have hindered our understanding of the exact neuropathology related to aMCI. Objectives: Our aim was to systematically review the literature reporting VBM on aMCI to elucidate consistent gray matter alterations, their functional characterization, and corresponding co-activation patterns. Methods: The PubMed, Web of Science, and EMBASE databases were searched for VBM studies on aMCI published from inception up to June 2020. Peak coordinates were extracted from clusters that showed significant gray matter differences between aMCI patients and healthy controls (HC). Meta-analysis was performed using seed-based d mapping with the permutation of subject images (SDM-PSI), a newly improved meta-analytic method. Functional characterization and task-based co-activation patterns using the BrainMap database were performed on significant clusters to explore their functional roles. Finally, VBM was performed based on the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset to further support the findings. Results: A total of 31 studies with 681 aMCI patients and 837 HC were included in this systematic review. The aMCI group showed significant gray matter atrophy in the left amygdala and right hippocampus, which was consistent with results from the ADNI dataset. Functional characterization revealed that these regions were mainly associated with emotion, cognition, and perception. Further, meta-regression analysis demonstrated that gray matter atrophy in the left inferior frontal gyrus and the left angular gyrus was significantly associated with cognitive impairment in the aMCI group. Conclusions: The findings of gray matter atrophy in the left amygdala and right hippocampus are highly consistent and robust, and not only offer a better understanding of the underlying neuropathology but also provide accurate potential biomarkers for aMCI.

Dataset Information

Cognitive Status, Gray Matter Atrophy, and Lower Orthostatic Blood Pressure in Older Adults.

Publications

Cognitive Status, Gray Matter Atrophy, and Lower Orthostatic Blood Pressure in Older Adults.

Similar Datasets

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