Ontology highlight
ABSTRACT:
SUBMITTER: Parker MW
PROVIDER: S-EPMC5545932 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Parker Matthew W MW Botchan Michael R MR Berger James M JM
Critical reviews in biochemistry and molecular biology 20170117 2
Cellular DNA replication is initiated through the action of multiprotein complexes that recognize replication start sites in the chromosome (termed origins) and facilitate duplex DNA melting within these regions. In a typical cell cycle, initiation occurs only once per origin and each round of replication is tightly coupled to cell division. To avoid aberrant origin firing and re-replication, eukaryotes tightly regulate two events in the initiation process: loading of the replicative helicase, M ...[more]