Ontology highlight
ABSTRACT:
SUBMITTER: Richner JM
PROVIDER: S-EPMC5546158 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Cell 20170701 2
The emergence of Zika virus (ZIKV) and its association with congenital malformations has prompted the rapid development of vaccines. Although efficacy with multiple viral vaccine platforms has been established in animals, no study has addressed protection during pregnancy. We tested in mice two vaccine platforms, a lipid nanoparticle-encapsulated modified mRNA vaccine encoding ZIKV prM and E genes and a live-attenuated ZIKV strain encoding an NS1 protein without glycosylation, for their ability ...[more]