Ontology highlight
ABSTRACT:
SUBMITTER: Richner JM
PROVIDER: S-EPMC5546158 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Richner Justin M JM Jagger Brett W BW Shan Chao C Fontes Camila R CR Dowd Kimberly A KA Cao Bin B Himansu Sunny S Caine Elizabeth A EA Nunes Bruno T D BTD Medeiros Daniele B A DBA Muruato Antonio E AE Foreman Bryant M BM Luo Huanle H Wang Tian T Barrett Alan D AD Weaver Scott C SC Vasconcelos Pedro F C PFC Rossi Shannan L SL Ciaramella Giuseppe G Mysorekar Indira U IU Pierson Theodore C TC Shi Pei-Yong PY Diamond Michael S MS
Cell 20170701 2
The emergence of Zika virus (ZIKV) and its association with congenital malformations has prompted the rapid development of vaccines. Although efficacy with multiple viral vaccine platforms has been established in animals, no study has addressed protection during pregnancy. We tested in mice two vaccine platforms, a lipid nanoparticle-encapsulated modified mRNA vaccine encoding ZIKV prM and E genes and a live-attenuated ZIKV strain encoding an NS1 protein without glycosylation, for their ability ...[more]