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Vaccine-mediated protection against Campylobacter-associated enteric disease.

ABSTRACT: Campylobacter coli and Campylobacter jejuni are responsible for 400 million to 500 million cases of enteric disease each year and represent the most common cause of bacterial gastroenteritis worldwide. Despite its global importance, Campylobacter vaccine development has been hampered by the lack of animal models that recapitulate human disease pathogenesis. Here, we describe a naturally occurring Campylobacter-associated diarrhea model in outdoor-housed rhesus macaques. Using this model, we developed novel next-generation H2O2-based Campylobacter vaccines that induced strong antibacterial antibodies to multiple Campylobacter proteins including flagellin and provided up to 83% protection against severe C. coli-associated diarrhea. Whole-genome sequencing of circulating Campylobacter strains revealed little to no homology within lipooligosaccharide or capsular polysaccharide loci with the Campylobacter vaccine strains used in these studies, indicating that vaccine-mediated immunity was not restricted to a single homologous serotype. Together, these results demonstrate an important advance in vaccine development and a new approach to reducing Campylobacter-associated enteric disease.

SUBMITTER: Quintel BK

PROVIDER: S-EPMC7314533 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Vaccine-mediated protection against Campylobacter-associated enteric disease.

Quintel Benjamin K BK Prongay Kamm K Lewis Anne D AD Raué Hans-Peter HP Hendrickson Sara S Rhoades Nicholas S NS Messaoudi Ilhem I Gao Lina L Slifka Mark K MK Amanna Ian J IJ

Science advances 20200624 26

Campylobacter coli and Campylobacter jejuni are responsible for 400 million to 500 million cases of enteric disease each year and represent the most common cause of bacterial gastroenteritis worldwide. Despite its global importance, Campylobacter vaccine development has been hampered by the lack of animal models that recapitulate human disease pathogenesis. Here, we describe a naturally occurring Campylobacter-associated diarrhea model in outdoor-housed rhesus macaque ...[more]

PMID: 32637610

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Dataset Information

Vaccine-mediated protection against Campylobacter-associated enteric disease.

Publications

Vaccine-mediated protection against <i>Campylobacter</i>-associated enteric disease.

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