Updated meta-analysis of the role of APOE ?2/?3/?4 alleles in frontotemporal lobar degeneration.
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ABSTRACT: We performed an updated meta-analysis to assess the role of the ?2/?3/?4 alleles of Apolipoprotein E gene (APOE) in frontotemporal lobar degeneration (FTLD). The relevant articles were retrieved from PubMed, CENTRAL, EMBASE and Web of Science databases, and 51 eligible case-control studies with 5123 cases and 20566 controls were selected after screening according to inclusion and exclusion criteria. Our analysis demonstrated that APOE ?4 was associated with increased FTLD risk in all genetic models (?4 vs. ?3 allele, ?4 vs. ?2 allele, ?4 vs. ?2+?3+?4 allele, ?4 vs. ?2+?3+?4 carrier, ?4?4 vs. ?3?3, ?3?4 vs. ?3?3, ?3?4+?4?4 vs. ?3?3, ?4?4 vs. ?3?3+?3?4, all P < 0.01, odds ratio [OR] > 1). Subgroup analysis revealed significant association between APOE ?4 and FTLD (P < 0.01, OR > 1) for the Caucasian, Italian, population based (PB), P > 0.05 value of the Hardy-Weinberg Equilibrium (HWE), Newcastle-Ottawa scale score > 6, and behavioral variant frontotemporal dementia (bvFTD) subgroups. However, there was no significant association between the APOE ?2 allele and FTLD (P > 0.05) in most genetic models and sub-group analyses. Begg's and Egger's tests also revealed no publication bias, and sensitivity analysis showed that our data analysis was robust. Thus our meta-analyses suggest that APOE ?4 is a genetic risk factor in patients with FTLD.
SUBMITTER: Su WH
PROVIDER: S-EPMC5546436 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
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