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?2 allele and ?2-involved genotypes (?2/?2, ?2/?3, and ?2/?4) may confer the association of APOE genetic polymorphism with risks of nephropathy in type 2 diabetes: a meta-analysis.

ABSTRACT: BACKGROUND:Diabetic nephropathy (DN) contributes to end-stage renal failure. Microvascular injury resulted from reactive oxygen species is implicated in the pathogenesis of DN. Genetic polymorphism of Apolipoprotein E (APOE) influences the antioxidative properties of the protein. The relationship of APOE polymorphism with the risks of nephropathy in type 2 diabetes (T2DN) remains elusive. METHODS:An up-to-date meta-analysis was conducted on the basis of studies selected from PubMed, WanFang database, Embase, Vip database, Web of Science, Scopus, and CNKI database. RESULTS:A total of 33 studies conferring 3266 cases and 3259 controls were selected on the basis of criteria of inclusion and exclusion in this meta-analysis. For APOE alleles, the pooled odds ratio (OR) of ?2 vs. ?3 was 1.89 (95% confidence intervals [95% CI]: 1.49-2.38, P?

SUBMITTER: Shi J 

PROVIDER: S-EPMC7293775 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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ε2 allele and ε2-involved genotypes (ε2/ε2, ε2/ε3, and ε2/ε4) may confer the association of APOE genetic polymorphism with risks of nephropathy in type 2 diabetes: a meta-analysis.

Shi Jikang J   Cheng Zhaorui Z   Qiu Shuang S   Cui Heran H   Gu Yulu Y   Zhao Qian Q   Ren Yaxuan Y   Zhang He H   Sun Helin H   Liu Yunkai Y   Li Yong Y   Qiao Yichun Y   Hu Yueyang Y   Liu Yawen Y   Cheng Yi Y  

Lipids in health and disease 20200613 1

<h4>Background</h4>Diabetic nephropathy (DN) contributes to end-stage renal failure. Microvascular injury resulted from reactive oxygen species is implicated in the pathogenesis of DN. Genetic polymorphism of Apolipoprotein E (APOE) influences the antioxidative properties of the protein. The relationship of APOE polymorphism with the risks of nephropathy in type 2 diabetes (T2DN) remains elusive.<h4>Methods</h4>An up-to-date meta-analysis was conducted on the basis of studies selected from PubMe  ...[more]

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