Ontology highlight
ABSTRACT:
SUBMITTER: Brzosko Z
PROVIDER: S-EPMC5546805 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Brzosko Zuzanna Z Zannone Sara S Schultz Wolfram W Clopath Claudia C Paulsen Ole O
eLife 20170710
Spike timing-dependent plasticity (STDP) is under neuromodulatory control, which is correlated with distinct behavioral states. Previously, we reported that dopamine, a reward signal, broadens the time window for synaptic potentiation and modulates the outcome of hippocampal STDP even when applied after the plasticity induction protocol (Brzosko et al., 2015). Here, we demonstrate that sequential neuromodulation of STDP by acetylcholine and dopamine offers an efficacious model of reward-based na ...[more]