Ontology highlight
ABSTRACT:
SUBMITTER: Charrasse S
PROVIDER: S-EPMC5547116 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Charrasse Sophie S Gharbi-Ayachi Aicha A Burgess Andrew A Vera Jorge J Hached Khaled K Raynaud Peggy P Schwob Etienne E Lorca Thierry T Castro Anna A
Nature communications 20170808 1
The Greatwall/Ensa/PP2A-B55 pathway is essential for controlling mitotic substrate phosphorylation and mitotic entry. Here, we investigate the effect of the knockdown of the Gwl substrate, Ensa, in human cells. Unexpectedly, Ensa knockdown promotes a dramatic extension of S phase associated with a lowered density of replication forks. Notably, Ensa depletion results in a decrease of Treslin levels, a pivotal protein for the firing of replication origins. Accordingly, the extended S phase in Ensa ...[more]