Ontology highlight
ABSTRACT:
SUBMITTER: Lee SY
PROVIDER: S-EPMC5547221 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Lee Seon Yong SY Kim Jun-Kyum JK Jeon Hee-Young HY Ham Seok Won SW Kim Hyunggee H
Molecules and cells 20170721 7
CD133, a pentaspan transmembrane glycoprotein, is generally used as a cancer stem cell marker in various human malignancies, but its biological function in cancer cells, especially in glioma cells, is largely unknown. Here, we demonstrated that forced expression of CD133 increases the expression of <i>IL-1β</i> and its downstream chemokines, namely, <i>CCL3</i>, <i>CXCL3</i> and <i>CXCL5</i>, in U87MG glioma cells. Although there were no apparent changes in cell growth and sphere formation <i>in ...[more]