Ontology highlight
ABSTRACT:
SUBMITTER: Eizenberg-Magar I
PROVIDER: S-EPMC5547583 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Eizenberg-Magar Inbal I Rimer Jacob J Zaretsky Irina I Lara-Astiaso David D Reich-Zeliger Shlomit S Friedman Nir N
Proceedings of the National Academy of Sciences of the United States of America 20170717 31
During cell differentiation, progenitor cells integrate signals from their environment that guide their development into specialized phenotypes. The ways by which cells respond to complex signal combinations remain difficult to analyze and model. To gain additional insight into signal integration, we systematically mapped the response of CD4<sup>+</sup> T cells to a large number of input cytokine combinations that drive their differentiation. We find that, in response to varied input combination ...[more]