Ontology highlight
ABSTRACT:
SUBMITTER: Haas LT
PROVIDER: S-EPMC5547898 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Cell reports 20170701 1
Metabotropic glutamate receptor 5 (mGluR5) has been implicated in Alzheimer's disease (AD) pathology. We sought to understand whether mGluR5's role in AD requires glutamate signaling. We used a potent mGluR5 silent allosteric modulator (SAM, BMS-984923) to separate its well-known physiological role in glutamate signaling from a pathological role in mediating amyloid-β oligomer (Aβo) action. Binding of the SAM to mGluR5 does not change glutamate signaling but strongly reduces mGluR5 interaction w ...[more]