Ontology highlight
ABSTRACT:
SUBMITTER: Kelly E
PROVIDER: S-EPMC5916364 | biostudies-other | 2018 May
REPOSITORIES: biostudies-other
Kelly Elyza E Schaeffer Samantha M SM Dhamne Sameer C SC Lipton Jonathan O JO Lindemann Lothar L Honer Michael M Jaeschke Georg G Super Chloe E CE Lammers Stephen Ht SH Modi Meera E ME Silverman Jill L JL Dreier John R JR Kwiatkowski David J DJ Rotenberg Alexander A Sahin Mustafa M
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20171205 6
Drugs targeting metabotropic glutamate receptor 5 (mGluR5) have therapeutic potential in autism spectrum disorders (ASD), including tuberous sclerosis complex (TSC). The question whether inhibition or potentiation of mGluR5 could be beneficial depends, among other factors, on the specific indication. To facilitate the development of mGluR5 treatment strategies, we tested the therapeutic utility of mGluR5 negative and positive allosteric modulators (an mGluR5 NAM and PAM) for TSC, using a mutant ...[more]