Ontology highlight
ABSTRACT:
SUBMITTER: Fujita T
PROVIDER: S-EPMC5548093 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Fujita Takeo T Liu Weijun W Doihara Hiroyoshi H Wan Yong Y
International journal of cancer 20090801 4
Dysregulation of the ubiquitin-proteasome system (UPS) has been implicated in several types of tumorigenesis. Our previous studies have shown the potential role of Cdh1/APC in regulating tumor formation via governing the Skp2-p27-cyclinE/CDK2 axis. In this work, we used a xenograft mouse breast cancer model to identify the mechanism by which Cdh1/APC potentially suppresses tumor growth in vivo. Here, we report that depletion of Cdh1 results in a significant enhancement of the breast tumor prolif ...[more]