Ontology highlight
ABSTRACT:
SUBMITTER: Kapishnikov S
PROVIDER: S-EPMC5548722 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Kapishnikov Sergey S Grolimund Daniel D Schneider Gerd G Pereiro Eva E McNally James G JG Als-Nielsen Jens J Leiserowitz Leslie L
Scientific reports 20170808 1
A key drug target for malaria has been the detoxification pathway of the iron-containing molecule heme, which is the toxic byproduct of hemoglobin digestion. The cornerstone of heme detoxification is its sequestration into hemozoin crystals, but how this occurs remains uncertain. We report new results of in vivo rate of heme crystallization in the malaria parasite, based on a new technique to measure element-specific concentrations at defined locations in cell ultrastructure. Specifically, a hig ...[more]