Ontology highlight
ABSTRACT:
SUBMITTER: Jha R
PROVIDER: S-EPMC5550222 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Jha Rajneesh R Singh Monalisa M Wu Qingling Q Gentillon Cinsley C Preininger Marcela K MK Xu Chunhui C
Stem cell reports 20170801 2
Understanding molecules involved in differentiation of human pluripotent stem cells (hPSCs) into cardiomyocytes and endothelial cells is important in advancing hPSCs for cell therapy and drug testing. Here, we report that LGR5, a leucine-rich repeat-containing G-protein-coupled receptor, plays a critical role in hPSC differentiation into cardiomyocytes and endothelial cells. LGR5 expression was transiently upregulated during the early stage of cardiomyocyte differentiation, and knockdown of LGR5 ...[more]