Genetic variation at the CD28 locus and its impact on expansion of pro-inflammatory CD28 negative T cells in healthy individuals.
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ABSTRACT:
SUBMITTER: Liaskou E
PROVIDER: S-EPMC5550460 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
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Genetic variation at the CD28 locus and its impact on expansion of pro-inflammatory CD28 negative T cells in healthy individuals.
Liaskou Evaggelia E Jeffery Louisa L Chanouzas Dimitrios D Soskic Blagoje B Seldin Michael F MF Harper Lorraine L Sansom David D Hirschfield Gideon M GM
Scientific reports 20170809 1
The CD28 locus is associated with susceptibility to a variety of autoimmune and immune-mediated inflammatory diseases including primary sclerosing cholangitis (PSC). Previously, we linked the CD28 pathway in PSC disease pathology and found that vitamin D could maintain CD28 expression. Here, we assessed whether the PSC-associated CD28 risk variant A (rs7426056) affects CD28 expression and T cell function in healthy individuals (n = 14 AA, n = 14 AG, n = 14 GG). Homozygotes for the PSC disease ri ...[more]
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