?? T Cells: Unexpected Regulators of Cancer Development and Progression.
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ABSTRACT:
SUBMITTER: Fleming C
PROVIDER: S-EPMC5551453 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Publications
γδ T Cells: Unexpected Regulators of Cancer Development and Progression.
Fleming Christopher C Morrissey Samantha S Cai Yihua Y Yan Jun J
Trends in cancer 20170717 8
Accumulating evidence suggests a role for gamma delta (γδ) T cells as unexpected drivers of tumor development and progression. These protumoral γδ T cells are abundant in the tumor microenvironment in both mouse and human. They promote tumor progression by: (i) inducing an immunosuppressive tumor microenvironment and angiogenesis via cytokine production; (ii) functioning as regulatory T (Treg)/T helper 2 (Th2)-like cells; (iii) interfering with dendritic cell (DC) effector function; and (iv) inh ...[more]
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