Ontology highlight
ABSTRACT:
SUBMITTER: Mendez DL
PROVIDER: S-EPMC5551479 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Mendez Deanna L DL Akey Ildikó V IV Akey Christopher W CW Kranz Robert G RG
Biochemistry 20170519 22
Cytochrome c (cyt c) has two important roles in vertebrates: mitochondrial electron transport and activating the intrinsic cell death pathway (apoptosis). To initiate cell death, cyt c dissociates from the inner mitochondrial membrane and migrates to the cytosol. In the cytosol, cyt c interacts stoichiometrically with apoptotic protease activating factor 1 (Apaf-1) and upon ATP binding induces formation of the heptameric apoptosome. It is not clear however what the redox state of cyt c is when i ...[more]