Ontology highlight
ABSTRACT:
SUBMITTER: Weiner DJ
PROVIDER: S-EPMC5552240 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Nature genetics 20170515 7
Autism spectrum disorder (ASD) risk is influenced by common polygenic and de novo variation. We aimed to clarify the influence of polygenic risk for ASD and to identify subgroups of ASD cases, including those with strongly acting de novo variants, in which polygenic risk is relevant. Using a novel approach called the polygenic transmission disequilibrium test and data from 6,454 families with a child with ASD, we show that polygenic risk for ASD, schizophrenia, and greater educational attainment ...[more]