Ontology highlight
ABSTRACT:
SUBMITTER: Bhagi-Damodaran A
PROVIDER: S-EPMC5553066 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Bhagi-Damodaran Ambika A Kahle Maximilian M Shi Yelu Y Zhang Yong Y Ädelroth Pia P Lu Yi Y
Angewandte Chemie (International ed. in English) 20170504 23
Heme-copper oxidase (HCO) is a class of respiratory enzymes that use a heme-copper center to catalyze O<sub>2</sub> reduction to H<sub>2</sub> O. While heme reduction potential (E°') of different HCO types has been found to vary >500 mV, its impact on HCO activity remains poorly understood. Here, we use a set of myoglobin-based functional HCO models to investigate the mechanism by which heme E°' modulates oxidase activity. Rapid stopped-flow kinetic measurements show that increasing heme E°' by ...[more]