Ontology highlight
ABSTRACT:
SUBMITTER: Katchman BA
PROVIDER: S-EPMC5553208 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Katchman Benjamin A BA Barderas Rodrigo R Alam Rizwan R Chowell Diego D Field Matthew S MS Esserman Laura J LJ Wallstrom Garrick G LaBaer Joshua J Cramer Daniel W DW Hollingsworth Michael A MA Anderson Karen S KS
Proteomics. Clinical applications 20160517 7
<h4>Purpose</h4>Mutations in TP53 induce autoantibody immune responses in a subset of cancer patients, which have been proposed as biomarkers for early detection. Here, we investigate the association of p53-specific autoantibodies with multiple tumor subtypes and determine the association with p53 mutation status and epitope specificity.<h4>Experimental design</h4>IgG p53 autoantibodies (p53-AAb), were quantified in 412 serum samples using a programmable ELISA assay from patients with serous ova ...[more]